By A. T. Florence, E. G. Salole
Concentrates on these medicinal drugs utilized in chemotherapy, their equipment of program and the impact of the sickness on their motion. This publication is aimed toward somebody concerned with the meting out of cytotoxic medicinal drugs, in addition to pharmacists at any point
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Extra resources for Pharmaceutical Aspects of Cancer Chemotherapy. Topics in Pharmacy
G. the lipophilic analogue of the anticancer drug cisplatin codenamed L-NDDP. Cisplatin is one of the most successful anticancer agents available, having curative potential in testicular cancer and good activity in ovarian and lung cancers, but it suffers from severe nephrotoxicity as well as the problem of pleiotropic drug resistance. However, L-NDDP is a water insoluble analogue and is almost completely inactive when administered as non-entrapped drug in a micellar suspension. Liposomal-L-NDDP is as active as cisplatin against animal tumour models, is non-cross resistant, and in dogs produces no significant renal dysfunction.
Preclinical antitumor activity of a soluble etoposide analog, BMY-40481-30. Investigational New Drugs, 8(Suppl. 1), S25-S32, 1990 Senter, P. , Schreiber, G. , Hirschberg, D. , Ashe, S. , Hellstrom, K. E. and Hellstrom, I. Enhancement of the in vitro and in vivo antitumor activities of phosphorylated mitomycin C and etoposide derivatives by monoclonal antibody -alkaline phosphatase conjugates. Cancer Research, 49, 5789-5792, 1989 Senter, P. , Saulnier, M. , Schreiber, G. , Hirschberg, D. , Brown, J.
Phillips, J. -M. and Roe, D. J. Plasma phamnacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized crossover trial. Cancer Research, 47, 2723-2726, 1987 51. Clark, L. and Waxman, D. J. Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation. Cancer Research, 49, 2344-2350, 1989 52. Norpoth, K. Studies on the metabolism of isophosphamide (NSC-109724) in man. Cancer Treatment Reports, 60, 437-443, 1976 53.