By E. Edward Bittar (Eds.)
With the present emphasis in melanoma learn on oncogenes and suppressor genes, and on autocrine elements and their receptors, one can finish that the ''whole story''can be learn within the melanoma telephone per se. nobody might deny that the super fresh advances in describing the molecular and mobile adjustments in melanoma cells have significantly additional to our realizing of neoplasia. yet, studying find out how to translate the which means of those changes into methods of treating and, higher but, fighting melanoma would require not less than as deep an realizing of the context during which it develops. the subjects of this quantity have been chosen to guide the reader throughout the advanced sequence of occasions in which melanoma cells and their ''environment''interact to supply malignant ailment. Underlying subject matters are the range within the pathways which may bring about malignancy and the elemental heterogeneity of neoplastic phone populations. As has usually been acknowledged, in melanoma no generalizations are constantly real (including this one). hence, many of the chapters has to be considered as examples of attainable approaches and mechanisms, no longer as universally appropriate legislation.
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Growth in medium without growth factor supplementation was highly dependent on the concentration of cell inocula suggesting autocrine factors produced by group I cells were important in permitting growth. Conditioned medium from the group I cells grown without factor supplementation obviated the inoculum dependence further supporting this hypothesis. Altered Growth Regulation in Cancer Cells 39 Group I11 cells were unable to survive in serum free medium without growth factor supplementation. Adaptation of the Cell Line Bank to Continuous Maintenance and Growth in Serum Free Chemically Defined Medium.