Home Inorganic • Alkaloids: A Treasury of Poisons and Medicines by Shinji Funayama, Geoffrey A. Cordell

Alkaloids: A Treasury of Poisons and Medicines by Shinji Funayama, Geoffrey A. Cordell

By Shinji Funayama, Geoffrey A. Cordell

Alkaloids are a wide staff of structurally advanced usual items showing a variety of organic actions. the aim of Alkaloids: A Treasury of toxins and drugs is to categorise, for the 1st time, the alkaloids remoted from the common assets in the past. The booklet classifies the entire alkaloids through their biosynthetic origins. Of curiosity to the natural chemistry and medicinal chemistry groups concerned with drug discovery and improvement, this publication describes many alkaloids remoted from the medicinal vegetation, together with these utilized in eastern Kampo medicine.

  • Classifies and lists alkaloids from average sources
  • Occurrence and biosynthetic pathways of alkaloids
  • Indicates key makes use of and bioactivity of alkaloids

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Extra info for Alkaloids: A Treasury of Poisons and Medicines

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Fukumoto, Chem. Commun. 289 (1971). [5] E. Leete, A. Ahmad, J. Am. Chem. Soc. 88 (1966) 4722. R. B. A. Widdowson, J. Chem. Soc. (C) 1213 (1970). R. J. A. Widdowson, J. Chem. Soc. Perkin Trans. I 346 (1974). S. N. Singh, J. Chem. Soc. Perkin Trans. I 618 (1978). [9] K. Ito, H. Furukawa, H. Tanaka, Chem. Pharm. Bull. 19 (1971) 1509. 13  Lycoris spp. AND LYCORINE Some Amaryllidaceae plants possess a group of alkaloids containing a C6– C2–N–C1–C6 unit. In this unit, the C6–C2–N moiety is derived from tyrosine or tyramine, and the C6–C1 part is derived from phenylalanine through cinnamic acid, p-coumaric acid, and protocatechualdehyde [1].

Guinaudeau, M. Leboeuf, A. Cave, J. Nat. Prod. 46 (1983R) 761. [5] H. Guinaudeau, M. Leboeuf, A. Cave, J. Nat. Prod. 51 (1988R) 389. [6] H. Guinaudeau, M. Leboeuf, A. Cave, J. Nat. Prod. 57 (1994R) 1033. 7  Aristolochia SPP. AND ARISTOLOCHIC ACID Aristolochia debilis (Aristolochiaceae) is a perennial vine that grows wild in the plains and on the banks of the rivers in Japan. The dried roots are called “Sei-mokkoh” or “Do-sei-mokkoh,” and the dried fruits are called “Ba-torei,” and are used in Kampo medicine.

19 (1971) 1509. 13  Lycoris spp. AND LYCORINE Some Amaryllidaceae plants possess a group of alkaloids containing a C6– C2–N–C1–C6 unit. In this unit, the C6–C2–N moiety is derived from tyrosine or tyramine, and the C6–C1 part is derived from phenylalanine through cinnamic acid, p-coumaric acid, and protocatechualdehyde [1]. Tyramine (C6–C2–N unit) and protocatechualdehyde (C6–C1 unit) are then combined and methylated to form O-methylnorbelladine, which is a common biosynthetic precursor of various Amaryllidaceae alkaloids.

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