By Shirley V. Hodgson, William D. Foulkes, Charis Eng, Eamonn R. Maher (auth.)
This is a entire and updated consultant to the analysis, scientific positive aspects and administration of inherited issues conferring melanoma susceptibility. it really is absolutely up-to-date with a lot molecular, screening and administration info. It covers threat research and genetic counselling for people with a relations historical past of melanoma. It additionally discusses predictive trying out and the enterprise of the melanoma genetics provider. there's information regarding the genes inflicting Mendelian melanoma predisposing stipulations and their mechanism of motion. It goals to supply such information in a pragmatic structure for geneticists and clinicians in all disciplines.
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Additional info for A Practical Guide to Human Cancer Genetics
2011; Abdel-Rahman et al. 2011). Familial uveal melanoma is now thought to account for 2–5 % of all cases (Harbour 2012). Meningioma Intraorbital meningioma is an uncommon tumor that may present at any age but predominantly occurs in middle-aged women. Most tumors are unilateral, but a small proportion of patients have bilateral involvement. Optic nerve sheath meningioma may complicate NF2 (see p. 293), when it is usually unilateral but can be bilateral (Jain et al. 2010). References Abdel-Rahman MH, Pilarski R, Cebulla CM, Massengill JB, Christopher BN, Boru G, Hovland P, Davidorf FH.
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The genetic landscape of the childhood cancer medulloblastoma. Science. 2011;331:435–9. Perri P, Bachetti T, Longo L, Matera I, Seri M, Tonini GP, Ceccherini I. PHOX2B mutations and genetic predisposition to neuroblastoma. Oncogene. 2005;24(18):3050–3. Peyster RG, Ginsberg F, Hoover ED. Computed tomography of familial pinealoblastoma. J Comput Assist Tomogr. 1986;10:32–3. Pulst SM, Rouleau GA, Marineau C, Fain P, Sieb JP. Familial meningioma is not allelic to neurofibromatosis 2. Neurology. 1993;43(10):2096–8.